Shortly after Prozac became the best-selling drug in the world in the early 1990s, I proposed that there was little or no evidence for efficacy, but considerable evidence that the drug would worsen depression and cause severe behavioral abnormalities. I attributed much of the problem to “compensatory changes” in neurotransmitters as the brain resists the drug effect. Since then, in a series of books and articles, I’ve documented antidepressant-induced clinical worsening and some of its underlying physical causes. Now the idea has gained ground in the broader research community and has recently been named “tardive dysphoria.”

Final sentencing for the teenager who inexplicably murdered his friend while on Prozac occurred November 4, 2011. The case involved a Winnipeg, Canada teenage high school student with no prior history of violence who, while chatting in his home with two friends, abruptly stabbed one of them to death with a single wound to the chest.