New Research: Antidepressants Can Cause Long-Term Depression
Shortly after Prozac became the best-selling drug in the world in the early 1990s, I proposed that there was little or no evidence for efficacy, but considerable evidence that the drug would worsen depression and cause severe behavioral abnormalities. I attributed much of the problem to “compensatory changes” in neurotransmitters as the brain resists the drug effect. Since then, in a series of books and articles, I’ve documented antidepressant-induced clinical worsening and some of its underlying physical causes. Now the idea has gained ground in the broader research community and has recently been named “tardive dysphoria.”